King’s College London (KCL) is one of the United Kingdom’s most prestigious university institutions: a multi-faculty research-led university college, ranked as one of the world’s top 25 universities that offers an intellectually rigorous environment. The Liver Science Department at King’s College London is closely linked to the Institute of Liver Studies (ILS) at King’s College Hospital, renowned globally for managing one of the largest liver disease programmes of all causes. The Department contains fully equipped laboratories and state- of-the-art animal facilities. We are part of the MRC Centre for Transplantation, which combines basic and applied immunological research, and is leading in the clinical development of cellular therapies in transplantation. The Liver Science Department also participates in the NIHR Comprehensive Biomedical Research Centre (BRC) at Guy’s and St Thomas Trust, which has been awarded a total of £64.4 million over 5 years from 2017 to build on its excellence in translational research. This gives access to an increased pool of patients for trial recruitment, state of the art clinical research facilities and unparalleled multidisciplinary collaborations in liver research.
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Role in ORGANTRANS
KCL will be responsible for the validation of the tissue in patient-derived serum and for development of clinical application actionable plan. Furthermore, they will participate in definition of specifications, liaise for regulatory authorities and define an optimal clinical design for a future first-in-man application.
Alberto Sanchez Fueyo is professor in Hepatology and the Leader of the department of Liver Studies. His main research interests include Hepatocyte Biology: developing hepatocyte transplantation for children with liver-based metabolic disorders, Liver immunopathology: investigating immune mechanisms involved in autoimmune hepatitis; primary biliary cirrhosis; viral hepatitis; and acute liver failure, Liver Molecular Genetics: investigating the molecular basis of cholestasis and bile formation.