ORGANTRANS

Controlled Organoids transplantation as enabler for regenerative medicine translation
ORGANTRANS

Start date: 1st January 2020
Duration of the project: 36 months

Abstract:
End-stage liver failure is a major healthcare challenge. Liver diseases account for approximately 2 million deaths per year worldwide. Liver transplantation is the most effective way to re-establish a liver with normal functions for various diseases including acute liver failure or liver malignancies. Currently, less than 10% of global transplantation needs are met and the gap between patients on transplant waiting lists and available donor organs is steadily increasing.
ORGANTRANS proposes a disruptive alternative to donor organs for patients with chronic or end-stage liver diseases who have still to isolate autologous liver stem cells. Driven by a need of leading European transplant centers, ORGANTRANS is tackling current obstacles for liver regenerative medicine by combining advanced know-how in cell biology, biomaterials, bioengineering, automation, standardization and clinical translation.
ORGANTRANS is developing a liver tissue printing platform that will be shortly deployed under the “compassionate use exemption” by three leading European transplant centers belonging to the consortium or the External Advisory Board. ORGANTRANS will not only deliver an ATMP, but also platform technologies that can be scaled to other organ systems, as organoid technology is one of the largest parts of regenerative medicine. The project covers the entire value chain (from cell source, tissue engineering, bioprinting, post-processing to testing) allowing for early adoption of its results (product & process) in clinical practice. The platform will first be scaled to Europe and then to the rest of the world.

List of participants:

N. Participant organisation name Short name Country
1 CSEM CENTRE SUISSE D’ELECTRONIQUE ET DE MICROTECHNIQUE SA – RECHERCHE ET DEVELOPPEMENT CSEM Switzerland
2 UNIVERSITEIT UTRECHT UUNetherlands
3 DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DWIGermany
4 REGENHU SA RHU Switzerland
5 VIB VZW VIB Belgium
6 KING’S COLLEGE LONDON KCL United Kingdom
7 KUGELMEIERS AG KUG Switzerland
8 AMIRES SRO AMI Czech Republic
Contact persons: Coordinator: Project Manager:
Name Dr. Gilles Weder Martina Nešverová
Organisation CSEM AMI
Email gilles.weder@csem.ch nesverova@amires.eu

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874586, project ORGANTRANS.